EVALUATION OF ANTI-CCP FOR EARLY DIAGNOSIS AND ASSESSMENT OF DISEASE SEVERITY IN RHEUMATOID ARTHRITIS PATIENTS

Abstract:
Rheumatoid Arthritis is a severe, progressive, systemic inflammatory disease of unknown etiology characterized by chronic and erosive polyarthritis by tissue or pannus and causes irreversible joint disability. The diagnosis of RA, particularly early in the course of disease is empirical and imprecise. A study was carried out on 100 patients who were presented with polyarthritis were divided into two groups. 50 patients who fulfilled the ARA criteria for RA were included in Group A.  Again 50 patients who had polyarthritis but not fulfilled the ARA criteria were included in Group B. The anti-CCP antibody was analyzed in relation to its sensitivity and specificity and also with different activity markers of RA. It was found that the specificity and sensitivity of Anti CCP was of RA were significantly correlated (DAS 28 score r=0.912; CRP, r=0.323; and VAS, r=0.382) with the increasing titer of Anti CCP (p<0.01). ESR was not correlated with the increasing moderate sensitivity in the early presentation of RA. So it can be used as a reliable serological marker for early diagnosis of RA. The increasing titre also significantly correlated with increased disease activity markers. So anti serological marker for early diagnosis and assessment of disease severity.
 Copyright©2017, Mohammad Nezam Uddin et al. This unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Further reading click here








Comments

Post a Comment

Popular posts from this blog

Serum Erythropoietin Level in Chronic Kidney Disease Patients with Anemia: A Baseline Study at Chittagong Medical College, Chittagong, Bangladesh

Image
Abstract: Chronic kidney disease (CKD) is a serious condition associated with premature mortality, decreased quality of life, and increased health-care expenditures. A failure to produce sufficient Erythropoietin (EPO) accounts for the moderate to severe anemia observed in chronic kidney disease. Decreased EPO production is attributed to the destruction of renal production sites. A cross-sectional descriptive study was designed for the determination of erythropoietin levels in chronic kidney disease patients with anemia. At the same time measurement of serum iron and serum ferritin to establish anemia. The serum concentration of erythropoietin was the parameter taken to evaluate the kidney status. This study was carried out in the Nephrology ward, Chittagong Medical College Hospital (CMCH), Chittagong, Bangladesh during the period of January 2012 to December 2012. Total Sixty Patients having hemoglobin level < 11 gm/dl and serum creatinine > 3 mg/dl taken as a case of chronic ki...
Read more

Postprandial Hypertriglyceridemia among Type-2 Diabetes Mellitus Patients of Chittagong, Bangladesh

Image
ABSTRACT  Diabetes mellitus (DM) is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. A case-control study was carried out in Chittagong Medical College, Chittagong, Bangladesh during the period of January 2012 to December 2012. The samples were collected from the Department of Medicine, Chittagong Medical College Hospital. The age limits of the patients were from 30-70 years. The data were collected by a structured questionnaire including age, sex, blood pressure, total cholesterol. Total numbers of patients were 90 of which 50 were considered as cases (All type-II diabetic patients having (i) age 30-70 years (ii) Fasting blood sugar ≥ 7...
Read more

Outcome of Surgical Management in Compound Depressed Skull Fractures With Primary Bone Fragment Replacement

Image
Abstract: Head injury is one of the most common causes of death worldwide & compound depressed skull fracture is an important cause of mortality & morbidity in this regard. Gradual urbanization and industrialization along with poor traffic control, use of over dated malfunctioning vehicles, poor and unplanned road traffic systems and overall lack of awareness of the people regarding traffic systems increase RTA (Road Traffic Accident) along with head injury. Besides this, assaults fall from height, sports injuries, birth trauma, etc are also important causes of head injury in our country. Health professionals are always facing these patients with a head injury in their everyday practice. Modern imaging facilities support early treatment and lead the outcome of compound depressed fractures of the skull towards zero mortality. But in developing countries like us due to lack of good health infrastructure & neurosurgical service along with the scarcity of neurosurgeons, commun...
Read more