Postprandial Hypertriglyceridemia among Type-2 Diabetes Mellitus Patients of Chittagong, Bangladesh
ABSTRACT
Diabetes mellitus (DM) is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. A case-control study was carried out in Chittagong Medical College, Chittagong, Bangladesh during the period of January 2012 to December 2012. The samples were collected from the Department of Medicine, Chittagong Medical College Hospital. The age limits of the patients were from 30-70 years. The data were collected by a structured questionnaire including age, sex, blood pressure, total cholesterol. Total numbers of patients were 90 of which 50 were considered as cases (All type-II diabetic patients having (i) age 30-70 years (ii) Fasting blood sugar ≥ 7 mmol /L. (iii) Random blood sugar ≥11.1 mmol/L. (iv) 2 hrs. after oral glucose load is ≥ 11.1mmol/L and 40 controls (non-diabetic, age 30-70 years, absence of renal, liver and cardiovascular diseases). The study was designed to observe the postprandial triglyceride level in type-II diabetic patients. The mean fasting triglyceride level of cases was 210.70 (±19.5) and the 2hrs, 4hrs, and 6hrs after test meals were 238.9 (±22.75), 260.5 (±15.36), and 260.32 (±5.94) respectively. At the same time, the mean fasting triglyceride of the control was 173.75 (±19.86) and the corresponding mean of the control were 189.75 (±15.23), 174.38 (±16.49) and 173.88 (±15.79) mg/dl respectively. The fasting and postprandial (2hrs, 4hrs, and 6hrs) triglyceride levels were significantly higher than that of the corresponding control. There are also significant differences of triglyceride levels in fasting and 2hrs, 4hrs and 6hrs after test meal among the cases which indicated that the triglyceride levels remained elevated for longer postprandial duration. It is also observed that there is a tendency of raised triglyceride levels with time after a test meal in cases compared with that of controls; it is because insulin resistance is a feature of type-II diabetes mellitus (T2DM), which is responsible for triglyceride overproduction. Further reading click here
Diabetes mellitus (DM) is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. A case-control study was carried out in Chittagong Medical College, Chittagong, Bangladesh during the period of January 2012 to December 2012. The samples were collected from the Department of Medicine, Chittagong Medical College Hospital. The age limits of the patients were from 30-70 years. The data were collected by a structured questionnaire including age, sex, blood pressure, total cholesterol. Total numbers of patients were 90 of which 50 were considered as cases (All type-II diabetic patients having (i) age 30-70 years (ii) Fasting blood sugar ≥ 7 mmol /L. (iii) Random blood sugar ≥11.1 mmol/L. (iv) 2 hrs. after oral glucose load is ≥ 11.1mmol/L and 40 controls (non-diabetic, age 30-70 years, absence of renal, liver and cardiovascular diseases). The study was designed to observe the postprandial triglyceride level in type-II diabetic patients. The mean fasting triglyceride level of cases was 210.70 (±19.5) and the 2hrs, 4hrs, and 6hrs after test meals were 238.9 (±22.75), 260.5 (±15.36), and 260.32 (±5.94) respectively. At the same time, the mean fasting triglyceride of the control was 173.75 (±19.86) and the corresponding mean of the control were 189.75 (±15.23), 174.38 (±16.49) and 173.88 (±15.79) mg/dl respectively. The fasting and postprandial (2hrs, 4hrs, and 6hrs) triglyceride levels were significantly higher than that of the corresponding control. There are also significant differences of triglyceride levels in fasting and 2hrs, 4hrs and 6hrs after test meal among the cases which indicated that the triglyceride levels remained elevated for longer postprandial duration. It is also observed that there is a tendency of raised triglyceride levels with time after a test meal in cases compared with that of controls; it is because insulin resistance is a feature of type-II diabetes mellitus (T2DM), which is responsible for triglyceride overproduction. Further reading click here
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