A Study of Correlation between Proteinuria and Histological Findings in Lupus Nephritis Patient
Abstract:
Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune disease with a wide spectrum of clinical and immunological abnormalities including the development of autoantibodies against DNA and other nuclear antigens. All organ tissues may be involved but the skin, joints, heart, nervous system and kidneys are most commonly affected. Clinical evidence of renal disease occurs in 40 to 75% of patients with SLE. The persistent proteinuria is the most frequent sign of the LN (Lupus Nephritis) and occurs in 70% of patients. A study was done involved 30 patients of Lupus Nephritis hospitalized in the Nephrology department of Chittagong Medical College Hospital, Chittagong, Bangladesh, between May 2010 to April 2011 to find the correlation between proteinuria and the histological type of Lupus Nephritis. Dependent variables like proteinuria and independent variables like different histological types were analyzed by chi2, ANOVA and Pearson’s correlations test. All patients was found female. The average age of the patient was 27.17+_9.51 years. Positive ANA titer was found in 77% of patients and positive Anti Ds DNA titer in 100% of patients. The common histological type was found in class IV. We had found a positive correlation between the values of proteinuria with histological classes of Lupus Nephritis. Further reading click here
Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune disease with a wide spectrum of clinical and immunological abnormalities including the development of autoantibodies against DNA and other nuclear antigens. All organ tissues may be involved but the skin, joints, heart, nervous system and kidneys are most commonly affected. Clinical evidence of renal disease occurs in 40 to 75% of patients with SLE. The persistent proteinuria is the most frequent sign of the LN (Lupus Nephritis) and occurs in 70% of patients. A study was done involved 30 patients of Lupus Nephritis hospitalized in the Nephrology department of Chittagong Medical College Hospital, Chittagong, Bangladesh, between May 2010 to April 2011 to find the correlation between proteinuria and the histological type of Lupus Nephritis. Dependent variables like proteinuria and independent variables like different histological types were analyzed by chi2, ANOVA and Pearson’s correlations test. All patients was found female. The average age of the patient was 27.17+_9.51 years. Positive ANA titer was found in 77% of patients and positive Anti Ds DNA titer in 100% of patients. The common histological type was found in class IV. We had found a positive correlation between the values of proteinuria with histological classes of Lupus Nephritis. Further reading click here
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