Health and Research

Chemotherapeutic resistance of head and neck squamous cell carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2- antioxidant pathway activation Abu Shadat M. Noman , Rashed R. Parag , Muhammad I. Rashid , Sha fi qul Islam , Mohammad Z. Rahman , Ali A. Chowdhury , Afrin Sultana , Chandsultana Jerin , Ayesha Siddiqua , Lutfur Rahman , Junayed Nayeem , Sonam Akther , Sunanda Baidya , Rajib K. Shil , Mizanur Rahman , Afsana Shirin , Reaz Mahmud , S. M. Ikram Hossain , Sharmin A. Sumi , Ar fi na Chowdhury , Shabnam B. Basher , Abul Hasan , Shammy Bithy , Jannatul Aklima , Nabila Chowdhury , Muhammad N. Hasan , Tahmina Banu , Srikanta Chowdhury , Muhammad M. Hossain ,  Herman Yeger , Walid A. Farhat   and Syed S. Islam  Abstract Overexpression of epithelial cell adhesion molecule (EpCAM) has been associated with chemotherapeutic resistance, leads to aggressive tumor behavior, and results in an adverse clinical outcome. The molecular mechanism by which EpCAM enrichmen

Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer Abu Shadat M. Noman, Rashed R. Parag, Muhammad I. Rashid, Mohammad Z. Rahman, Ali A. Chowdhury, Afrin Sultana, Chandsultana Jerin, Ayesha Siddiqua, Lutfur Rahman, Afsana Shirin, Junayed Nayeem, Reaz Mahmud, Sonam Akther, Rajib K. Shil, Ikram Hossain, Sharmin Alam, Arfina Chowdhury, Shabnam B. Basher, Abul Hasan, Shammy Bithy, Jannatul Aklima, Mizanur Rahman, Nabila Chowdhury, Tahmina Banu, Bedri Karakas, Herman Yeger, Walid A. Farhat and Syed S. Islam Abstract Background: Sonic hedgehog (Shh) and Nrf2 play a critical role in chemotherapeutic  resistance. These two genes have been found to be dysregulated in head and neck squamous cell carcinomas (HNSCC). The purpose of this study was to analyze the expression, function and clinical prognostic relationship of Shh and Nrf2 in HNSCC in the