A Brief Analysis of PIK3CA Expression in Head and Neck Squamous Cell Carcinoma * Rahman MM 1 , Manzur MR 2 , Afrin N 3 , Parvin A 4 , Yasmin M 5 , Uddin MM 6 , Khan J 7 1. Dr. Md. Mizanur Rahman MBBS, M.Phil, PhD Associate Professor, Department of Biochemistry, RMC. 2. Dr. Md. Ruhul Manzur MBBS, M.Phil, Assistant Professor, Department of Biochemistry, RMC. 3. Dr. Nahida Afrin, MBBS, M.Phil, Assistant Professor, Department of Biochemistry, RMC. 4. Dr. Ayesha Parvin, MBBS, M.Phil, Lecturer, Department of Biochemistry, RMC. 5. Dr. Monira Yasmin, MBBS, M.Phil, Lecturer, Department of Biochemistry, RMC. 6. Dr. Mezbah Uddin, MBBS, M.Phil, Lecturer, Department of Biochemistry, RMC. 7. Dr. Md. Jahangir Khan, MBBS, M.Phil, Associate Professor, Department of Biochemistry, Sheikh Hasina Medical College, Habiganj. Corresponding author: Dr. Md. Mizanur Rahman MBBS, M.Phil, PhD Associated Professor, Department of Biochemistry, Rangamati Medical College. Email: mizan2011bio@gma...
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Chemotherapeutic resistance of head and neck squamous cell carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2- antioxidant pathway activation
Chemotherapeutic resistance of head and neck squamous cell carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2- antioxidant pathway activation Abu Shadat M. Noman , Rashed R. Parag , Muhammad I. Rashid , Sha fi qul Islam , Mohammad Z. Rahman , Ali A. Chowdhury , Afrin Sultana , Chandsultana Jerin , Ayesha Siddiqua , Lutfur Rahman , Junayed Nayeem , Sonam Akther , Sunanda Baidya , Rajib K. Shil , Mizanur Rahman , Afsana Shirin , Reaz Mahmud , S. M. Ikram Hossain , Sharmin A. Sumi , Ar fi na Chowdhury , Shabnam B. Basher , Abul Hasan , Shammy Bithy , Jannatul Aklima , Nabila Chowdhury , Muhammad N. Hasan , Tahmina Banu , Srikanta Chowdhury , Muhammad M. Hossain , Herman Yeger , Walid A. Farhat and Syed S. Islam Abstract Overexpression of epithelial cell adhesion molecule (EpCAM) has been associated with chemotherapeutic resistance, leads to aggressive tumor behavior, and results in an adverse clinical outcome. The molecular mechanism by which E...
Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer
Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer Abu Shadat M. Noman, Rashed R. Parag, Muhammad I. Rashid, Mohammad Z. Rahman, Ali A. Chowdhury, Afrin Sultana, Chandsultana Jerin, Ayesha Siddiqua, Lutfur Rahman, Afsana Shirin, Junayed Nayeem, Reaz Mahmud, Sonam Akther, Rajib K. Shil, Ikram Hossain, Sharmin Alam, Arfina Chowdhury, Shabnam B. Basher, Abul Hasan, Shammy Bithy, Jannatul Aklima, Mizanur Rahman, Nabila Chowdhury, Tahmina Banu, Bedri Karakas, Herman Yeger, Walid A. Farhat and Syed S. Islam Abstract Background: Sonic hedgehog (Shh) and Nrf2 play a critical role in chemotherapeutic resistance. These two genes have been found to be dysregulated in head and neck squamous cell carcinomas (HNSCC). The purpose of this study was to analyze the expression, function and clinical prognostic relationship of Shh and Nrf2 in HNSCC in ...
Food and Nutrition continuation
Vitamin B 1 (Thiamin pyrophosphate) 1. Antiberiberi factor: 1926 2. Absorption site: Jejunum/ileum 3. Biological half-life: 10-20 days. 4. Limited tissue storage so continuous supplementation is required. 5. Acts as oxidative carboxylase 6. Acts as co-enzyme with transketolase enzyme in HP shunt. 7. Cofactor for enzymes in arachidonic acid and CHO metabolism. Dietary source : Yeast, legumes, rice, cereals, etc. RDA : 1.2- 1.5 mg/day Deficiency: 1.Beriberi 2.Wernicke- Korsakoff syndrome Beriberi: Dry & Wet. Dry beriberi: Peripheral neuropathy of extremities. Wet beriberi: due to heart failure—cardiomegaly, cardiomyopathy, tachycardia, pitting peripheral edema. Wernicke encephalopathy : Chronic alcoholic, horizontal nystagmus, ophthalmoplegia, gait ataxia, confusion. Korsakoff psychosis: recent memory loss. Vitamin B12 1. Stored in the body as a flavoprotein 2. Poorly soluble in water. Function: FMN & FAD act as coenzyme. Source: M...
1st Year MBBS -Food and nutrition (Cont. from previous)
Body Mass Index (BMI) Weight in Kg Height in sq.M 1. Normal : 18.5-24.9 2. Overweight: >25-30 3. Obese: >30-40 4. Grossly obese: >40 5. Ideal: 22-23.5 Balanced diet : The approximation of all proximate principles of food proportionately is called a balanced diet. 1. Contain sufficient energy. 2. Protein: One-third 1 st class protein 3. Fat: One third fat 4. Energy: 50-60% CHO, 20-30% fat. Lipid Profile 1. Cholesterol: < 200 mg/dl 2. HDL: >40 mg/dl 3. LDL: <100 mg/dl 4. TG : <150 mg/dl Calculation of total energy equivalents Following steps are necessary: 1. Determine the IBW (ideal body weight). 2. Calculation of REE(Resting energy equivalent) 3. Substrate 0.1 kcal/kg/hr x IBW x sleeping hour. 4. ...